The 46 went away as teams learned how to exploit it. Offenses and defenses and variations of them have come and gone. Always will. It's the equivalent of predator/prey evolution. Sooner or later the sabre toothed cat gets reinvented again and again.
And it's true you need players with talent to win in any scheme.
But I don't think it's true you can put a talented player in any position and expect them to excel equally at each position. I'm speaking of moving say a LB to any LB spot in any scheme. Some players play at higher levels at one position in a certain scheme and don't do well if moved around.
Not sure I'm getting that across properly.
Did you know there are only 5000 Snow Leopards in the wild now and they are confined to Central Asia? However, the effective global population (those likely to reproduce) is less than half that number.