I should add this
Bud Foster at Virginia Tech quickly found a way to "beat" the Rich Rod spread being run at WVU.
WVU had success against VT in 2003, but then struggled against the VT D in 2004 and 2005 (the last times the team played)
Part of it was talent, the VT defense got much better at the LB spots in 2004 and 2005. And that is the key to me, having superior linebacker play.
In the end superior athletes will win out, which is why GT and its triple option always struggles against UGA and other SEC teams, the caliber of athletes are better.
In the NFL you do NOT have that type of discrepancy in talent, and if you do it is rare. A team like the 49ers with its front 7 might be it right now, Justin Smith can dominate the LOS.