Currently according to NFL rules, a team designates 46 of its 53 active roster players to be eligible to play in a game. I don't get the point of this. It seems like it would make more sense to simply allow any player from the 53-man roster to play in any game. Given the amount of injuries teams often sustain, this makes sense. It gives a team more depth. Note: Some of the sources I googled said it was 45 players who were eligible to play. Perhaps that's dated information or perhaps it's 45 plus an emergency QB who are eligible? I wasn't quite sure. In any event, it seems to make more sense to simply allow any player from the 53-man roster to play.