There will likely be no agent Starling, in name at least. There are weird copyright issues with Silence of the Lambs and they are not allowed to use any of those names. So unless something changes (which seems unlikely at this point) whoever Agent Starling is, will have a different name, as will Buffalo Bill, etc. So Buffalo bill will likely be a different serial killer, and I'm sure they'll change his MO, and Starling will go by a different name. Plenty of change already. So far they've done a fantastic job of separating themselves from the movies, so I kind of trust them to take it where they want to go. Silence of the Lambs is projected to be season 5, with Hannibal being 6, and an ending being season 7.