I disagree. Protein (amino acids) lasts about 3 hours in the bloodstream. That is the fuel for muscle growth. If you are working out and building muscle you need that fuel to stay in your bloodstream. Building muscle is also key to weight loss as muscle burns more calories. Also, long gaps between meals or eating only once a day will put your body into starvation mode, limiting the burning of calories. You also put your body into a highly catabolic state (muscle wasting). Also, you are left hungry, which then can lead to binge eating or snacking on poor food choices. I've done the 5 meals a day. If you count calories and plan out each meal accordingly, the weight will literally melt off.