Poe will undoubtedly go top 20.
Even well-trained guys 350+ seldom look great on tape versus 250 pound guys. They don't have the motor or stamina to go all out for an entire game and get double-teamed to prevent their biggest advantage.
Vince Wilfolk is the last really big guy I can think of who put up good stats. And he was a freak playing with other NFL defensive talent that couldn't consistently get double-teamed.
NFL teams have to make a decision on Poe and will be a tough one for even experienced NFL scouts. Fans really should just shut up about the guy because we are clueless. Accurately analyzing and projecting 350 pound guys is a painfully rare skillset.
I can almost assure you the guy rated highest in this draft class for Bill Parcells would be Dontari Poe. BP uses the 'rare human theory' and favors big guys with even a modicum of athleticism over everything.