Stunningly, some of the most successful microfracture patients seem to be some of the earliest. The available evidence points to Hall of Famer Dan Marino having microfracture in 1986, just three years into his Hall of Fame career. Though Marino had not missed a start the previous two seasons, he had undergone multiple operations on his left knee after injuring it at Pitt. More surgeries followed, but Marino was able to play on the knee for 17 seasons. Rod Woodson apparently underwent a microfracture procedure in April 1991. Despite rehab and a holdout that lasted until late August, he was in the starting lineup for the Steelers' opener and played 13 more years in the NFL.
The most successful 1990s return from microfracture might be much more obscure, however. Lepsis, a tight end at Colorado, suffered a knee injury in the 1997 Senior Bowl and underwent microfracture shortly thereafter. Lepsis hooked on with the hometown Broncos, was moved to tackle, and missed only one start between 1999 and 2005. (When Lepsis ran into knee problems last year, it was his other knee; he tore his ACL and underwent microfracture on that knee as well.)
Obviously age isn't a positive factor for returning from microfracture, but several players 30 or older have made successful comebacks, led by Bruce Smith. The long-time Bills defensive end had microfracture surgery in February 1998 at age 34. He returned to play six more seasons and earn his final trip to the Pro Bowl. Tom Nalen underwent the procedure in conjunction with repairing a torn ACL at age 31 in November 2002 and has started every Denver game since returning the following season.
Fifteen players have undergone a microfracture in their 30s. Five of them failed to return to the field, but eight of the 21 players to undergo a microfracture at 25 or younger have never returned. Younger players have averaged more games after surgery -- 33.7 to 26.3, not counting players who are just returning this season.