You play a team twice in the Super Bowl ... and lose both times. One of the losses is a major blowout. In the second one, your "leaders" short-circuit and let a halftime lead get away and you lose handily again.
A few years later, you trade two picks (including a first-rounder) to the same team to move up in the draft to select a quarterback whom you believe is the future of your franchise.
That other team uses those two picks to select a dynamic franchise-type running back and a talented defensive lineman with a bright future.
You waive your starting quarterback because you're sure that the young quarterback you drafted is ready to handle the job.
That same team then picks up your old quarterback and he is playing well for them.
You've never won a Super Bowl, despite having four chances ... in a row. The greatest player in franchise history also happens to be an accused double-murderer.
Must suck to be Buffalo.