The big advantage of the no-huddle is the defense cannot easily make substitutions. If you can use the same personnel for your 1st, 2nd and 3rd down offense by simply using different formations, it will prevent the defense from being able to make situational substituions.
I like our ability to do this with a few different combinations of skill players:
MB3/Felix/Witten/TO/WR2
MB3/Witten/Bennett/TO/WR2
MB3/Deon/Witten/TO/WR2
The reason why this works for us is Witten's ability to act as a 3rd WR when we need him to. Felix may be able to do the same. Bennett also has the athletic ability to do this.
When we come in with these heavy packages, we will force the defense to stay in their base defense lest they create a mismatch in the running game. If they want to bring in a situational pass rusher, he'll also have to play against us on 1st and 2nd down. Ditto for a nickle corner.
I would propose we could run no-huddle but not necessarily run it fast like in a 2-minute offense. We could just go to the line, make our call and then run the play. By not huddling, the defense does not have time to do their substitutions. Since we are controlling the ball, we don't really have to give up any potential advantage we are generating in TOP.