Anyone watch it?
Did anyone follow the comics and have a clue what is going on?
If you have read the comic...does it get better and start to make more sense down the road as it was really kind of discombobulated and crazy in the pilot.
It's been a decade since reading it but discombobulated is what I felt as well. I thought the first episode looked really good visually but was pretty flat and inefficient in terms of setting up characters and relationships. It was a solid launch episode and I'm hopeful enough to watch some more.
Short answer: Too soon to say.
What's going on?
In the various church scenes around the world, a supernatural force was seeking an appropriate vessel that could contain it. It enters the body of various religious leaders. They are found wanting and they explode (RIP Tom Cruise). What we see in the scene at the end is it has finally found a home within Jesse Custer and this force provides Jesse with a power equivalent to the Word of God. This empowers Jesse to command others to his bidding. The mystery men that investigate the churches post-explosion are a secret society. Can't recall if they're an arm of the Vatican or a kind of Knights Templar or something else. In the comics they are tasked with the preservation of Christ's bloodline and preparing for the rapture I think.
Does it make more sense down the road?
In the comics, it made sense in issue 1. The reader is immediately introduced to the three main characters as an already established group. The reader is brought up to speed on who these characters are and what the stakes are within the first few pages. You get some backstory in the form of flashbacks. Jesse's a much more together anti-hero and more immediately accessible. He's a badass. They're on the move, in part because they have a purpose and in part because some folks are coming after Jesse. Some of the character changes concern me. Cassidy is not vampire James Bond. I'll also say it's much easier for me to understand Cassidy in print vs listening to him.
The comic is an Apocalypse Now of the American South & West kind of story with a supernatural element. It is a world spanning -- and otherworldly spanning -- story in the comics. They did it some in episode 1 but I don't know if they'll have that kind of budget to do it often. If they have to stay in one place more in order to work around the budget, it could get monotonous. They also might play down the supernatural aspects or keep them vague, which would undermine the show to me.
There's also significant social commentary and satire in the comics. Arseface is basically a tragicomic vehicle for skewering everything and anything that set off the writer, Garth Ennis. Unclear how much they'll do that on the show.
and reread it recently as a refresher. I didn't think the pilot was confusing but without reference I get it is. It all makes sense in the comics and for that platform had nice character development. Not sure if they can pull that off in the tv as Tulip is already some feminist wet dream. In the books she is a lot more realistic and doesn't do stupid crap like make bazookas. 
