Lets work out your scenario - I am assuming the QB, RB, WR players are playing at least shotgun depth or even a little deeper on the sides.
1. If the D only has 2 defenders to play your players on the side (TE, OL, WR/RB/QB), then they are risking a huge play every time. Even if there is a huge blitz, all our QB has to do is recognize it and launch the ball to the side with less defenders. So I dont believe that is a credible threat.
2. In terms of the 5 defenders with blitzing in the middle, it is also very dangerous. If the blitzers are coming between the OL, then Zeke simply has to release to the side for a huge play. If the blitzers come from both edges, Zeke can read and release further to the side and has 1 blitzer to beat for a big play. If the blitzers come from one edge, Zeke can read and release to the other side, again another big play.
Did that make any sense?