It has the potential. I mean, at this point, losing to the Cardinals potentially could mean losing any shot at home-field advantage. If you want to fret over the unknown, that's your prerogative. I think it's mostly silly to worry about these early-season games. Sure, you'd rather win them than lose them, but neither means that much at this point. There are no must-win games the first quarter of the season. And by that, I mean we could start 2-4 and if we turned it around and went 11-0 from there, maybe we have home-field advantage, maybe we are on our way to the Super Bowl.
I still look back at the 2007 season where the Giants knocked us off the Super Bowl path. The Giants were just a subpar team halfway through that season, turned it around and won a Super Bowl. Losses at this point really only hurt you if you are not the team you hope to be at the end of the year. If you are, then it doesn't matter if you have to hit the road to reach the Super Bowl.