My own thang...
When I lived in LA, I lived in an area (West Hollywood, on Hollywood Blvd) where everything was basically within walking distance.
4 blocks to work. 1 block to the grocery store.
2 blocks to clubs and restaurants. 3 blocks from Graumann's Chinese Theater.
Half a block to church. Screw your religion, there was 3 denominations all within that half-block.
Jewish, Christian and Muslim. I actually saw recently that the Christian church has been converted to a night club...
Only time I got in a car was to go to the piers, or the beach, but I never hit the highways. I hit the streets.
Savvy people know how to traverse.
That's a little smaller than most live within but most don't live "in the city:", they live in part of the city and only venture into other parts on a needs basis.
When I first started traveling to NYC, that was eye opening as to just how far people would go to chase a dream. I mainly called on ad agencies with my rep and talking to these young buyers, an entry level position for most, about their lifestyles was mind boggling. If they lived in the city, they usually had anywhere from 2-4 roommates in close quarters and only having lived with one woman I could not even imagine that but when they talked about being in NY, they lit up. They could not imagine being anywhere else. Others, that commuted, had anywhere from 1.5-2.5 hours each way, each day. They had little, if any, weekday life which was why all of the social talk centered around what happened last weekend or what was on for this one.
One thing that used to puzzle me about NYC before I actually spent any time there was why in every movie I ever saw were the characters always carrying a brown paper bag of groceries, most of the time with a loaf of bread sticking out the top and sometimes a stalk of celery. Why didn't they go to the store once a week like everybody else? I didn't consider the storage issue.
The other thing was if everything in NYC was so expensive, how in the hell did people live there? I heard about the $5 Coke as a teenager and thought everyone must be millionaires. And it took traveling there and hanging with a friend from there to really know how most New Yorkers made it work.
Like SZ, I do dig the hustle and bustle of the city, the energy, but it took getting away from it to understand the effect on me. It's like hanging in Vegas for a few days in one of the strip hotels. You begin to get used to the sounds of the slots and general noise and it affects one's thinking. You get away from it and you can actually form more cohesive thoughts.
I detest noise pollution and it affects my mood. It is as if I have to find a void in it for thought. Tell ya what else I don't like and didn't realize this until I was away form it, the light pollution in the larger cities. I got down here, went outside one night and looked up and freaked, how long have all those stars been there? Damn, so many.
And there's the personal side. As strange as it sounds, I am less lonely alone than in large crowds of people.