I bet on a per carry/per game basis, AD has been no more injury prone than anyone else. Its not hard to stay healthy when you're just getting 15-20 touches a game in some tandem platoon sharing system. Other RB's drafted in the 1st round in recent year .... Addai, Maroney, Cadillac, Ronnie Brown, Lynch, Reggie Bush, LenDale White. ... they were all in split workload systems in college.
Its hard for people to understand if they didn't get a chance to see him on a weekly basis, but when AD was good to go there were games where I swear he was 85% of OU's offense. He would get 35 rushes a game, and be just as fresh and crisp on his 35th carry as his 5th. His freshman year he broke the All Time NCAA record for freshman carries. Even with the injuries and coming out early, he's still 2nd all time in carries at OU and this is a school that ran the wishbone for most of their history and has produced Heisman Trophy winning runningbacks. In a way, the injuries might have been the best thing that happened to him because it kept Stoops from just ruining him. Not many elite RB's, even in college, see even close to that kind of workload.
He wont get nearly the workload in the NFL as he did in college. Chester Taylor is a great compliment as a nickel/3rd down back, and more than capable of spelling AD for 2-3 series a game. If he'll just learn to run a little smarter at the end of runs (go out of bounds instead of trying to end DB's careers, just go down instead of trying to carry 9 defenders for another half a yard) he'll be fine on the injury front. You can teach that stuff. You can't teach freak of nature talent. Even when he's nicked up and 80%, he's still better than most backs.