That's difficult and dangerous. If he beats you off the line before you make contact, then you're done. You're not going to catch up. You would have to find somebody that it not the primary coverage guy to bump him, but that tends to take that player away from other duties. I've seen a DE move out and bump a guy while leaving the actual coverage to the players behind him. Obviously, that takes your DE out of pass rushing.
It definitely would be risky to take that approach.
I didn't make it sound as complex as it would be in my original post but I still think that it is the best way to attack players like Woodhead and Sproles and what they bring to the table.
A defense would have to pick its spots against them, but I'd basically tell my players on defense to hit them whenever they encountered them on the field, abiding by the rules of course. In our case, Woodhead has beaten one on one coverage off the line nine times out of 10 and has found the soft spots in our zone when we played it. Nothing we did really slowed him down when we played San Diego last year and the same thing happened last night even though it was a preseason game so I'd take my chances hitting him as much as I could.
There are alot of things a coach could do to generate contact with a running back like them, but that's the big question every time we face a player of those calibers. We have no idea how to play them and they run free.
If Danny Woodhead or Darren Sproles are going to stay in to help block on certain plays, I am going to make sure my players make it a point to hit them pretty good. If we bring a blitz and one of my players was going by him en route to the QB as he flanked out to the flats, I'd make sure he got plowed a few times during that process, if not every time.