Just my opinion....
Offense: Pull a page out of Mike Leach's playbook. Go with somewhat of a spread that involves Romo operating out of the shotgun more times than not, with 3/4/5 wide sets. That forces Seattle to go deep into their horribly depleted secondary and also will give Romo a lot of opportunities to run out of the pocket where he is most dangerous. Throw in a delayed draw to barber/Jones every now and then, maybe a few misdirection runs out of 3+ wide sets, etc. Force an injured defense to spread out and play the run, the pass, and the running QB every play.
Defense: Blitz early, blitz often, blitz all day. Hasslebeck WILL eat us up if we try and play coverage, so why force a few sacks and turnovers along the way by blitzing? We're gonna give up some big plays either way, might as well put pressure on them along the way. Also, use RW as your main blitzer off the edge and on delayed blitzes. Show a vlitz from Ayodele or Carp, then drop them back deep in place of Roy and have Roy come up on the blitz. It doesnt have to be elaborate, just force them to choose between a LB and a safety and hope they choose wrong.