There was a TV report where they followed some NFL refs around. It seemed obvious that there was a lot more "human condition" involved than we would like to see. I remember one guy saying something like "I didn't call that because they were losing big anyway". IMO, the status of the game shouldn't affect the calls by the refs, but this guy was acknowledging that it does.
I realize that it's not an easy job, but it doesn't seem nearly as difficult as being an NBA ref.
There are a few general concepts that seems to be a problem.
1. Error on the side of not blowing the play dead too soon. (How hard is this?).
2. Error towards less borderline type penalties at the end of the game in critical situations (not more).
3. Don't be afraid to get it right on replay review. Nobody cares if you were wrong initially as long as you get it right with the replay review.
I can't begin to explain why the ref would not call the penalty. Maybe because the game was so lopsided he noticed this with the players ont he field and just wanted to help the game end earlier. Can't say for sure.
On blowing the play dead too soon. Is it just a matter of them being so eager to blow contact plays dead to stop play and avoid injury that its a reflexive reaction they have to all plays.
If the game is in a critical situation I can only surmise the players feel it, the fans feels it and clearly the refs must feel it also. Everyone's adrenaline is pumping and some errors are probably made inside this pressure cooker.
The review part is still perplexing to me. I personally don't get it, but I wish there was an open discussion on individual reviews so the transparency would help the league and the refs get to better results. It won't stop errors, but I would hope that the review is the best chance for calls to go the right way.
Each year the plays accumulated gives the competition committee fodder to decide which plays they are going to add to the review board. I would hope the almost fumbles by St. Louis and other plays similar would be consider by the refs and the league.
With all the investment in technology they do have a responsibility to get it right.