Our last trade up hasn't worked out so well, at least as of yet. Mo has been quite a disappointment. Too bad, as he was my favorite CB in the draft and I was actually pleased when we moved up to get him.
If we were one or two players away from serious SB contention, I would definitely consider trading up, if a player of want is there. However, we have several holes to fill, especially on defense and tons of dead money on the cap (limiting our ability to be a big time player in the FA market).
We need to be frugal with our picks. Instead of trading up and sacrificing multiple picks, I am ok with trading down a few times and adding a few more picks. However, whether we stand pat or trade down, we must make sure and hit on at least 90 to 95% of our picks. We have little room for error since some of our recent drafts have been complete disasters (2009 comes to mind).