I'd take him because he would easily be the best player available and what it means to have a top back has been shown this year, but if he's not there, I wouldn't mind seeing us trade down slightly and take a DT like Harmon. The more I read, the more I think only one DT is worthy of a top 10 pick, but there are a few in the 18-25 range. If we stick where we are and Jeanty is gone, it's looking like an OL or WR will be the best value, possibly DE.
I'd prefer we get our WR in free agency, and I think after spending a first on an OL last year, I'd rather not repeat that this year. I could be talked into DE, even though we took Kneeland in the second, because we need a second consistent pass-rushing threat. But I don't think the pass rushers will matter much if we can't stop the run. I'd make it my plan to use two of our first three picks on DTs, especially if we don't re-sign Odighizuwa.