Inside would always be best..Simply quicker to the QB and also right in their faces. Can't throw when you cannot see. End rushers are a premium because that is simply where you have the best chance to get to a QB..DT who can rush the passer AND play the run are HOF players like Sapp and Randy White because it is so rare. End rushers, you can hide them in run defense a bit if they struggle against the run.
End rushing also takes more time so that allows the quick throws or ability to feel the rush and move in our out of the pocket. Cannot really do that when the middle is being pushed back into your face as a QB.