As a true freshman at TCU in 2020, Guyton redshirted, seeing action in only one game.[3] In 2021, he appeared in eight games, one as a starter, while splitting time between being a backup offensive lineman and H-back.[4][5] He caught a touchdown pass in a game against Iowa State.[6][7] In January 2022, Guyton transferred to the University of Oklahoma to play for the Oklahoma Sooners.[8]
In his first season for the Sooners, Guyton began the season as a left tackle while switching to right tackle by the end of it.[9] He appeared on a total of 400 snaps and allowed only two sacks and no quarterback hits.[10]