I had to look out of curiosity.
Since 2014, they've played 5 games.
Out of the 5, philly has won 3, san fran 2.
Total point win by philly for those 3 was 52 points
Total point win by 49'ers was 11 points
Personally, I think it will be a toss up because they're playing in philly and at the end of the day, say what you will about philly, they just don't seem to make as many stupid mistakes as their opponent and they don't give up (I would have bet at halftime they would have lost agasint the bills, and I don't bet).
Made me look at the cowboys vs 49'rs
Since 2014, san fan has won 4 and dallas won 3. Ironcially enough, out of those 4 the 49'ers have won, 3 of those wins have been over the last 2 years.