In the Bible Belt, religion plays a more prominent role (
link) and you'll see more of it in social situations / ceremonies that are treated as more secular elsewhere. You'll have people ask you to which church you go and you may encounter some people who want to help you find your church home. I'm not saying it is good, bad or a big deal, but probably it will differ from what you've encountered before.
Obviously you love football. College football in the Deep South truly is a great experience. You'll be located close to Clemson (and Furman). You owe it to yourself to give it a try -- Think about picking up some football season tickets. You'd have a great time and it'd help to get you acclimated.