If teams like Indiana and Maryland were on the schedule I'd be all for it. I simply don't see it working out well against NFL defenses though. The Cowboys basically ran this a few years ago when they introduced the Hulk package, and that worked with decent amount of success. Replacing better blockers with skill players typically wont work at this level. You really don't see many 2RB packages these days, moving to 3 doesn't seem like a great idea IMO. I could see some value in this package if you wanted to run it maybe 1-2 times per game. As the year goes on you could start to play off of it if there is any sort of success, and possibly be able to catch a matchup issue in the receiving game as you motion a player out, but I think that is about it.
What I think might be more realistic for the Cowboys to do is use a similar formation, but with TEs on the field, or possibly Luepke if he is able to make the roster this season. The Cowboys have the bodies to do something like this but in the NFL this is more of a power formation, where as in college it could be ran as more of a combo of power & finesse plays. This is the type of formation in the NFL that you hit teams with power run,run,run,run,run....play action to sneak a TE out for a pass uncovered. This with a bunch of finesse and misdirection is likely only going to work once or twice before teams catch on, and honestly may get blown up several times unless your Oline is top tier.