Oh yeah, forgot about the quick toss/sweeps/outside zone runs. You generally can spread the DL and motion your LBs to one side. Take control of the weakside LB and ensure you go wide of the LT/RT to protect against that cut back and put that WOLB on the LOS on the backside. If he runs strong side, you want to turn into the player closest to action and speed directly to the sideline to cut off that angle and then press the L trigger to get centered if you beat them outside to prepare for the tackle.
If someone keeps using that screen (cheeser type), take control of your MLB and watch the OL and cut off the path to the RB sprinting in his line of path or close proximity to make tackle, etc. (can lead to a lot of sacks).
But if you're not the MLB, (this is my preference btw but general rule is playing as DL is a lost play defensively; online exclusive/a lot of players play S exclusively and run all over the field to disrupt/confuse/play coverage, but those are hardcore OL/cheeser types) pre snap and they just mix it in a lot, take control of your LBs and watch the TE/RB and see which one should takes priority.
I forgot too, on running while playing offense, don't hit sprint until your OL makes contact (it causes the D to speed up/pursuit) so wait until they make contact bf making your cuts w/R stick raft inside/speed button. Think of sprinting as exclusive to outside runs (outside zones/power sweeps generally have the OL setup to allow you to sprint to the outside almost immediately or until you clear the rif inside and to finish off your runs to gain that couple of extra yards w/your R stick.
Holding L trigger while performing jukes, spins, trucks one on one helps you break tackles and can lead to long runs. Zeke inside I just hold L trigger until ready to truck/sprint/wiggle w R stick and just read the MLB to decide which side to run (usually good for 5-7 a pop). HB Dives/stretch/power O trap, and power sweep are probably the best running plays. You can audible your OL too, so on stretch plays make sure to either push R/L ( or up for inside) or to the side of your sweep and the OL will take a big step to help set up your blocks.