I have struggled with motion sickness all my life. As a kid in upstate NY the winding roads and limited panoramic views in routine car rides often made me sick.
Plane rides are hit and miss. Its largely dependent on how much turbulence we get. I still remember the pilot proudly declaring "that ride would have cost you an E ticket at Disneyland" as I wretched in my seat. Other times I've been just fine.
The risk part of flying is always on my mind but, but not paralyzing or debilitating in any way. BTW - that crap about "safer than driving"... brings me no comfort. If I'm driving I at least have some control.
Now that I live in Colorado, and am predominantly the driver, I rarely get motion sick. But on a recent road trip through the southwest I chose the scenic route through Moab Utah. Absolutely gorgeous, while I was upright. The roads were fairly straight - limited back and forth stuff. Problem was it was very hilly. Lots of quick ups and downs. I was even the driver but it probably took 15 minutes before I could no longer function and had to lay down in the back. Sicker than I'd been in quite some time. Got some meds in the next town and bounced back surprisingly well as those episodes can often linger for days with me. Of course the roads at that point were mostly straight and flat.
Motion sickness is a real drag. I actually got wiped out one day by motion sickness generated by me water-skiing!