All of the above, I arrive saturday a little after lunch and leave monday morning. So i was hoping to have a great time saturday night recover and then hit the tailgate and the game sunday evening. Maybe meet some philly ladies haha
University city which is the neighborhood near university of Penn is a spot with a lot of bars and generally packed with college kids and generally younger crowd, probably a good spot to pick up chicks.
Main street manayunk also can be a pickup spot - and the bars are pretty cool there, i think the bars on mainstreet are all very different and some have a really unique flare to them. So better bars on main street than University City, i think, But with a mixed age crowd - will still be younger folks there to meet. But probably more college age and young people partying in university city.
Old city has some really cool bars that show off the history of the city - but less of a pickup spot for younger people. But also closer to where you are staying.
So, as a suggestion....
i would grab some lunch at reading terminal, spend the afternoon either hanging around rittenhouse square and/or the art museum (not far from each other) or see the historic sites in old city (you wont have time for both).
At night, trek over to either university city or Main street manayunk and hang for a while, then as the night gets later you can head back east toward Old city and then finish the evening in some bars there since its closer to your hotel.
Personally I prefer manayunk to university city .