A couple of their offensive weapons have a history of being somewhat fragile. Samuels was injured a few times. McCafferty had a big one, although, he seems to be more reliable recently.
The odds of succeeding increase dramatically with the absence of one of the following four offensive players: Deebo Samuels, Christian McCafferty, George Kittle and Brandon Aiyuk.
The offensive players for the 49ers are very versatile but the team isn't very versatile in that they depend on large production from a few players.
The 49ers and Jags are the only two teams with three players with 50 or more receptions. On the other hand, the 49ers have only four players with 20 or more receptions. No other team has less.