Works for me... hell, I'd even think hard about trying to trade up from pick 45 to get your center of the future, Peter Konz... if you don't wish to give up draft picks to make that happen (I don't see any way Konz makes it to 45), then target Philip Blake in the 4th...
I know the defense needs help, and I would look to acquire some of that help later in the draft, but to me the quickest path to serious playoff contention lies in upgrading our offensive line... with the skill position players this team has, if you build a dominating offensive line this team will be unstoppable... usually, this would be a 2 or 3 year process, but you've got Tyron Smith already, DeCastro would certainly be another major building block, why not go all in and try to accelerate that process??
Hell, doing that might even help the defense's stats-- the other team can't score if you've got the ball... the more I think about it, the more I think drafting offensive line early is the way to go...
Tyron Smith at left tackle, Nate Livings at left guard... Philip Blake at center... David DeCastro at right guard, Doug Free at right tackle... I think the Boys could put up some good offensive numbers behind that offensive line... that's a big offensive line (almost 320 pounds per man), built to lean on people, but with the exception of Livings, the other four linemen can run pretty well, too...