If the team you're playing is much better than you, use high-risk high-reward strategies. Most likely, it won't work and you'll be completely embarrassed. But there's a small chance you hit the jackpot. Overall, your odds of winning are better than just playing them straight up and letting them beat you inexorably.
Hence, long passes to DeSean Jackson against double coverage.
The corollary being that you should go for it on 4th-and-1 deep in their territory instead of settling for a field goal. Oh well.