I can't see the logic in taking a TB or WR in the 2nd unless there was a clear steal there. So I don't think it would be wise to use a 2nd on either of those positions.
The OL is interesting. You could look for a solution for Smith but honestly, I think they might be better off along the OL than some think, assuming people are healthy. If Frederick is healthy, Looney can move to OG. I think I'd start giving Williams some reps as OT as well. Yes, people will claim he cant play OT because he has short arms but there are some pretty good OTs out there that don't have the prototypical long arms. They have options along the OL IMO but I could never complain about taking another OL, assuming an OT type. I think it would be kind of silly to take an OG.
LB would be a waste of a pick IMO. They have their two main LBs.
CB? Ehhhh. I was very bullish on Awuzie and he played a bit better down the stretch but if there is a stud CB there, I am not sure taking him would be bad. It would give you some flexibility with Jones............. maybe you don't want to hand over a massive contract to Jones at CB in order to keep the cap situation in decent shape.